M
Mark Newman
Founder and CEO of Precision Analytical, creator of the DUTCH Test (Dried Urine Test for Comprehensive Hormones)
6
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2
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012
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Sep 8, 2026
Functional Medicine Providers vs. AI: Using Both Without Perpetuating Myths
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9:48Jaclyn SmeatonHOST
Has the response softened or changed? When you had recommended this expanded hormone panel when Dutch first started, what was the receptivity like? And is it different now? Or do you find, no, we're really still getting the same level of pushback?
M
10:07Mark NewmanGUEST
I think like anything, it comes in like different camps of people of like Tars talking about people who are missing details.
M
10:15Mark NewmanGUEST
And for those people, there's this whole education process that you have to go through because you're missing something you don't know about.
M
10:22Mark NewmanGUEST
And then, and then there are people who like understand that, but really needed the testing and we were able to fill that spot.
M
10:29Mark NewmanGUEST
And then now the pendulum is, I don't know, and probably just, I have recency bias, but in terms of focusing on one of those things, just because you know about it and then applying it to everything is also like a big problem of, which is why the educated provider is such a key part of that.
M
10:45Mark NewmanGUEST
I have a, a family member that has Hashimoto's and another family member was like, Hey, this is something I found on social media.
15 MINS LATER
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25:39Jaclyn SmeatonHOST
Mark, are there things that you feel like they come up all the time on the Dutch test that people would just have never known or you could never suspect or guess without that testing?
Choosing the Right Progesterone Prescription: A Discussion on OMP & Vaginal Progesterone
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18:27Jaclyn SmeatonHOST
... that would be really helpful to clear up from a risk data perspective, and, and why what we're talking about today is something a little bit different.
M
18:34Mark NewmanGUEST
Yeah, maybe starting with that aspect of it is, I mean, just to keep it as simple as possible, different chemicals, um, you know, that have different impacts on the body.
M
18:44Mark NewmanGUEST
Um, and I, I mean, we always talk about how frustrating it is to read papers where they interchange them even to have the word progesterone in the title, um, and then as you get to page four, you're like, "Oh," you know, I get into the methodology and you're not talking about progesterone, you're talking about a progestin.
M
18:59Mark NewmanGUEST
So, you know, the body makes progesterone, um, and in a certain respect it works, uh, also to use a synthetic version of that.
M
19:07Mark NewmanGUEST
And so in the WHI study and, uh, in, in many practices, um, they reach for that, and there are reasons for that that might get into politics and all of that, which I will not get into.
M
19:17Mark NewmanGUEST
Um, just to say they're different compounds and different chemicals, um, and, you know, uh, the benefits of natural progesterone aren't, aren't completely mimicked by the, the synthetic progestins, although they do protect the uterus from, um, too much proliferation when you also have estrogen on board.
M
19:35Mark NewmanGUEST
So a lot of confusion over that over the years, um, and we could get more into that.
50 MINS LATER
The Saliva Testing Gap in Hormone Therapy: Clinical Outcomes & Solutions
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13:05Jaclyn SmeatonHOST
Mm-hmm.
M
13:05Mark NewmanGUEST
And, and from there, there are layers to this that get really confusing because progesterone doesn't go up when you give it topically in serum, but testosterone and estrogen do.
M
13:21Mark NewmanGUEST
And so that's-- not to get into-- I mean, there are other layers of this that we need to unpack, but that I think is really the genesis point of this.
M
13:28Mark NewmanGUEST
Um, and there-- and, and even from there, there are lots of confusing points that go-- So people will say, "When you take topical hormones, it doesn't show up in serum." And that is relative...
M
13:40Mark NewmanGUEST
I would say that is true of progesterone, but for estrogen and testosterone, um, it's not true.
50 MINS LATER
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63:35Jaclyn SmeatonHOST
Yeah.
The Estrogen Myth: Rethinking Hormone Therapy & Breast Cancer Risk
J
11:20Jaclyn SmeatonHOST
Can you talk a bit about that piece, Mark? And then I wanna shift back to talk about ca- breast cancer.
M
11:24Mark NewmanGUEST
Yeah, and just to double down on what you said, it's pretty frustrating when you read...
M
11:28Mark NewmanGUEST
I, I have seen somewhere, you read an abstract that uses the word progesterone, even in an, in an academic setting, and then as you peel down into the paper, then you see that they're actually not talking about, uh, progesterone, but they're...
M
11:39Mark NewmanGUEST
And so when people are drawing conclusions, even sometimes if you just read the abstract, you can actually be, uh, misled, even if you're w- [chuckles] even if you're well-intentioned.
29 MINS LATER
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40:54speaker_3ADVERTISER
Welcome back to the Dutch Podcast.
Closing Bell Overtime: Apple Takes Center Stage; Tech Wrap Up Strong Month 4/30/26
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32:02Mark NewmanGUEST
I mean, uh, actually, if you look at the numbers, it's not, uh, i- it's pretty, it's pretty close, and we actually, uh, from third party sources, we noted in our Apple tracker that the ASP was trending a little bit lighter than expected.
M
32:16Mark NewmanGUEST
So we actually expected that the iPhone revenue could've been actually worse than this.
M
32:24Mark NewmanGUEST
Um, obviously we need to go through a few more details to see what's trending and, and some of the details from the guidance we'll learn from the call.
M
32:31Mark NewmanGUEST
But that's what I'm gonna be looking out for really is, uh, the guidance for iPhone going into next quarter, um, a- a- and including the gross margin and, and how, how is that holding up given, as you said, memory headwinds and, and other things, uh, going on in the market.
Closing Bell Overtime: 3/27/26
M
33:59Mike SantoliHOST
You think that makes sense here? Uh, and I guess are there other reasons that you're recommending it?
M
34:05Mark NewmanGUEST
Yeah, I mean, it's, it's a stable, more defensive name, and part of the reason for that really is they never had this big upside from the AI boom that some of the other Mag Seven have had.
M
34:17Mark NewmanGUEST
Uh, and so when you hear about and f- uh, hear about there's this fears of the AI bubble bursting, Apple tends to do pretty well on those days.
M
34:31Mark NewmanGUEST
And I think similarly just due to its valuation, its constant EPS growth, and free cash flow growth, and its ability to con- constantly compound its EPS and free cash flow, uh, it's generally a pretty safe haven when you're seeing fears in the market like we are today.