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The Chronic Fatigue and Burnout Recovery Podcast

The Chronic Fatigue and Burnout Recovery Podcast

Episode 157: Could Creatine Support Energy and Cognitive Function in Long Covid?

Aug 21, 2026 · 30 min · 15 segments

Creatine is often associated with the fitness industry and sports performance — but emerging research is now exploring whether it may have relevance far beyond the gym. In this episode, Anna explores…

Creatine is often associated with the fitness industry and sports performance — but emerging research is now exploring whether it may have relevance far beyond the gym. In this episode, Anna explores the current evidence surrounding creatine supplementation in Long Covid and fatigue-related conditions, including its potential role in energy metabolism, muscle function, cognitive symptoms, nervous system health, and recovery capacity. This conversation also looks at: - Why creatine is being investigated in Long Covid - The link between ATP production and fatigue - Potential neuroprotective and antioxidant mechanisms - Brain fog and cognitive symptoms - Muscle weakness, PEM, and pacing considerations - Why individual responses to supplements can vary - Considerations around dosage, safety, and supplement sensitivity - Creatine and the menstrual cycle Importantly, this episode takes a balanced and non-dogmatic approach. While early research is promising, creatine is not presented as a “magic bullet” or standalone solution for Long Covid. As always, recovery is complex, individual, and multifactorial. This episode is intended for educational purposes only and should not replace personalised medical advice. **Useful Links** Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page Instagram: https://www.instagram.com/anna\\marsh\_ Work with me: https://annamarsh.co.uk/work-together/ Website: https://annamarsh.co.uk/ **Referenced Articles** Effects of six-month creatine supplementation on patient- and clinician-reported outcomes, and tissue creatine levels in patients with post-COVID-19 fatigue syndrome Reduced tissue creatine levels in patients with long COVID-19: A cross-sectional study Creatine Supplementation in Women’s Health: A Lifespan Perspective Creatine Supplementation and Brain Health Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome Role of Creatine Supplementation in Conditions Involving Mitochondrial Dysfunction: A Narrative Review

Creatine is often associated with the fitness industry and sports performance — but emerging research is now exploring whether it may have relevance far beyond the gym. In this episode, Anna explores…

Spotify Apple Podcasts YouTube Website

Speakers: Anna MarshHost

Top entities: Creatine×13 Adenosine triphosphate×10 chronic fatigue syndrome×8 Digital object identifier United States National Library of Medicine×2

Show signals: SuitabilitySafeAudience≈121 followers

What Is Long COVID?1:57 – 3:31

A

1:57

You probably already know by now that long COVID refers to a condition where individuals experience a range of symptoms that can continue for weeks or months or years after the initial COVID infection.

A

2:11

And symptoms can continue over time and they can fluctuate over time.

A

2:16

and may include but not be limited to things like fatigue, shortness of breath, chest pain, joint pain, and cognitive difficulties, often described as brain fog.

A

2:29

Some individuals may also experience ongoing inflammation or changes affecting multiple body systems.

A

2:37

Long COVID can affect people of all ages, regardless of the severity of their initial infection, and the exact mechanisms and duration can vary widely from person to person.

A

2:50

This can make it feel really confusing.

A

2:52

It can make it feel really unpredictable.

A

2:56

And as research into long COVID evolves, there is growing interest in interventions that may support energy production, cognitive function and recovery capacity.

A

3:08

And so that's really what I wanted to talk about today is I wanted to talk about creatine specifically and its role in energy production, its role in cognitive function and maybe managing or modulating the immune response in the body.

A

3:24

But before we go into all of that, let's just back up a few steps and talk a little bit about what is creatine.

CreatineEntityCompound
94%13 mentions
Adenosine triphosphateEntityCompound
83%10 mentions
chronic fatigue syndromeEntityDisability
72%8 mentions
Digital object identifierEntity
61%1 mention
United States National Library of MedicineEntityNational library in Bethesda, Maryland
50%2 mentions
National Center for Biotechnology InformationOrganization
39%1 mention
Sports nutritionEntityField of study
28%1 mention
InstagramSoftware ApplicationSocial networking service
17%2 mentions
iTunesSoftware ApplicationMedia player
6%1 mention

Effects on Energy ProductionHealth > Nutrition > Supplements > Creatine
Brain FogHealth > Cognitive Function
Energy MetabolismHealth > Cognitive Function > Brain Fog
Creatine's RoleHealth > Cognitive Function > Brain Fog > Energy Metabolism
ModulationHealth > Immune System
CreatineHealth > Immune System > Modulation
Anti-inflammatory EffectsHealth > Immune System > Modulation > Creatine
Creatine SupplementationHealth > Exercise Science > Muscle Recovery
Performance EnhancementHealth > Exercise Science > Muscle Recovery > Creatine Supplementation
Immune SystemHealth
Exercise ScienceHealth
Chronic IllnessHealth
FatigueHealth > Chronic Illness > Long COVID > Symptoms
Long COVIDHealth > Chronic Illness
Muscle RecoveryHealth > Exercise Science
CreatineHealth > Nutrition > Supplements
NutritionHealth
Cognitive FunctionHealth
SupplementsHealth > Nutrition
SymptomsHealth > Chronic Illness > Long COVID
Health

What Is Long COVID?1:57 – 3:31

A

1:57

You probably already know by now that long COVID refers to a condition where individuals experience a range of symptoms that can continue for weeks or months or years after the initial COVID infection.

A

2:11

And symptoms can continue over time and they can fluctuate over time.

A

2:16

and may include but not be limited to things like fatigue, shortness of breath, chest pain, joint pain, and cognitive difficulties, often described as brain fog.

A

2:29

Some individuals may also experience ongoing inflammation or changes affecting multiple body systems.

A

2:37

Long COVID can affect people of all ages, regardless of the severity of their initial infection, and the exact mechanisms and duration can vary widely from person to person.

A

2:50

This can make it feel really confusing.

A

2:52

It can make it feel really unpredictable.

A

2:56

And as research into long COVID evolves, there is growing interest in interventions that may support energy production, cognitive function and recovery capacity.

A

3:08

And so that's really what I wanted to talk about today is I wanted to talk about creatine specifically and its role in energy production, its role in cognitive function and maybe managing or modulating the immune response in the body.

A

3:24

But before we go into all of that, let's just back up a few steps and talk a little bit about what is creatine.

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