Sage Clinical Medicine & Research
Jul 15, 2026 · 2 min · 2 segments
Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826261424812
In this article, the authors present a hybrid surgical approach for transcatheter mitral valve replacement, TMVR, in the domestic SHIP model.
SHIP are the primary in vivo model for testing novel heart valve devices, though their mitral anatomy complicates TMVR device deployment.
And so the authors developed a hybrid surgical approach for TMVR in sheep to enable long-term evaluation prior to clinical investigation.
And this novel approach may overcome the model-related morbidity and mortality associated with performing TMVR percutaneously in the sheep model and facilitate long-term device evaluation required for regulatory approval.
So this article is accompanied by an inside-footed detail by Dr. Guimbertier and Capoulade from the Institut du Thorax in Inserm, Nantes, France, who considered that this hybrid surgical approach proposed by Carney and colleagues provides a valuable and reproducible framework for long-term evaluation of transcatheter mitral valves in large animal models.
And I stated that as TMVR technologies continue to evolve, such methodological advances will be essential to bridge the gap between innovation and safe clinical translation.
And really, we are in need for animal models to do the preclinical evaluation of the transcatheter procedure, especially the transcatheter mitovar procedure.
And so this article and this proposal of an hybrid model is very welcome and timely.
In this article, the authors present a hybrid surgical approach for transcatheter mitral valve replacement, TMVR, in the domestic SHIP model.
SHIP are the primary in vivo model for testing novel heart valve devices, though their mitral anatomy complicates TMVR device deployment.
And so the authors developed a hybrid surgical approach for TMVR in sheep to enable long-term evaluation prior to clinical investigation.
And this novel approach may overcome the model-related morbidity and mortality associated with performing TMVR percutaneously in the sheep model and facilitate long-term device evaluation required for regulatory approval.
So this article is accompanied by an inside-footed detail by Dr. Guimbertier and Capoulade from the Institut du Thorax in Inserm, Nantes, France, who considered that this hybrid surgical approach proposed by Carney and colleagues provides a valuable and reproducible framework for long-term evaluation of transcatheter mitral valves in large animal models.
And I stated that as TMVR technologies continue to evolve, such methodological advances will be essential to bridge the gap between innovation and safe clinical translation.
And really, we are in need for animal models to do the preclinical evaluation of the transcatheter procedure, especially the transcatheter mitovar procedure.
And so this article and this proposal of an hybrid model is very welcome and timely.
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