Did Your GLP-1 Stop Working? Appetite, Receptors and Weight-Loss Plateaus

Does a weight-loss plateau mean your GLP-1 receptors have become desensitized? John separates cellular receptor biology from whole-body weight regulation and compares semaglutide, tirzepatide, and investigational retatrutide. We examine appetite suppression, food noise, gastric-emptying tachyphylaxis, metabolic adaptation, switching therapies, and what the clinical evidence can—and cannot—tell us. A plateau is real. "Receptor burnout" is a much bigger claim. Educational only; not medical advice.