Tachyphylaxis

are much less likely to be long-term successful.

So, of course, will these drugs develop resistance or over time? Tachyphylaxis is the technical term for that.

But the orexin agonists so far seem to produce a more natural and stable wakefulness response.

Fewer side effects and less potential for abuse, certainly, than stimulants.

So it tends not to have as many side effects that you got from the others because the others that are part of it are in a lower dose.

You know, there's this fancy term called tachyphylaxis.

Tachyphylaxis means the longer you're on a medication, the less reactive you are to the side effects.

So we always say they can just get past the point and go to tachyflaxis, all that other stuff.

I agree.