Wow.

So we see a restoration of youthful musculature, an increase in strength.

Guys, older guys over 50 get about a 50% rise in testosterone.

Ladies get a rest- older ladies get a restoration of vaginal moisture and sensation.

There's an increase in libido, which leads to some very embarrassing stories.

Uh, there is, uh, a presumptive increase in the immune responses.

People seem to get better faster.

Wow

But people, oh my God, there's an epidemic about microbiome and being drunk and not having, and not drinking, right? Talk, talk about that.

[laughs] So I've spent a lot of time thinking about the microbiome's influence on what goes on in your internal dialogues and your behavior.

And the thing that really triggered me and got me really diving into this topic, besides some of my own clinical data- ... is the observation made many years ago, made in France in 19th century by a French pathologist.

He found a number of people who had intoxicated levels of ethanol in their blood, but they hadn't been drinking.

His, his observations were widely discussed, but dismissed pretty much.

It got resurrected in 1980s in Europe when there was a series of car accidents.

A 40-year-old Belgian man, for instance, wrapped his car around a tree, arrested, cuffed, and then he claimed he never had anything to drink.

Let, let people know.

But people, oh my God, there's an epidemic about microbiome and being drunk and not drinking, right? Talk about that.

so I spent a lot of time thinking about the microbiome's influence on what goes on in your internal dialogues and your behavior, and the thing that really triggered me and got me really diving into this topic, besides some of my own clinical data, is the observation made many years ago, made in France in the 19th century by a French pathologist.

He found a number of people who had intoxicated levels of ethanol in their blood, but they hadn't been drinking.

His observations were widely discussed, but dismissed, pretty much.

He got resurrected in 1980s in Europe when there was a series of car accidents.

A 40-year-old Belgian man, for instance, wrapped his car around a tree, arrested, cuffed, and then he claimed he never had anything to drink.

So he actually was formally studied.

Let people know.

But people, oh my God, there's an epidemic about microbiome and being drunk and not drinking, right? Talk about that.

so I spent a lot of time thinking about the microbiome's influence on what goes on in your internal dialogues and your behavior, and the thing that really triggered me and got me really diving into this topic, besides some of my own clinical data, is the observation made many years ago, made in France in the 19th century by a French pathologist.

He found a number of people who had intoxicated levels of ethanol in their blood, but they hadn't been drinking.

His observations were widely discussed, but dismissed, pretty much.

He got resurrected in 1980s in Europe when there was a series of car accidents.

A 40-year-old Belgian man, for instance, wrapped his car around a tree, arrested, cuffed, and then he claimed he never had anything to drink.

So he actually was formally studied.

Let people know.

But people, oh my God, there's an epidemic about microbiome and being drunk and not drinking, right? Talk about that.

so I spent a lot of time thinking about the microbiome's influence on what goes on in your internal dialogues and your behavior, and the thing that really triggered me and got me really diving into this topic, besides some of my own clinical data, is the observation made many years ago, made in France in the 19th century by a French pathologist.

He found a number of people who had intoxicated levels of ethanol in their blood, but they hadn't been drinking.

His observations were widely discussed, but dismissed, pretty much.

He got resurrected in 1980s in Europe when there was a series of car accidents.

A 40-year-old Belgian man, for instance, wrapped his car around a tree, arrested, cuffed, and then he claimed he never had anything to drink.

So he actually was formally studied.

Let people know.

I know that's not

true.

Yeah.

Well, you know, we've spent half a century, George May, half a century wasting our time with false and misleading concepts like cholesterol.

So the whole concept of cholesterol got its start over 50 years ago.

A lot of it done at the National Institutes of Health.

Right.

Yeah.

So Dr. Davis, from your point of view, what are some of the things that you're gonna recommend people to look at that maybe they haven't before? Obviously, we all know microbiome is one of the biggest ones for you.

So as you know, JJ, uh, just doing things the way people have been doing it for the last many decades does not work, or it yields temporary outcomes.

Such things as exercise more, move more, eat less, reduce your calories, push the plate away [laughs].

All the things that people thought.

And at first, right, at first blush, these things sound like they're, they're effective.

They're not.

They're temporary solutions.

So why don't you talk a little bit about some of the sessions you're gonna be presenting on the cruise and in this program?

So Dr. Davis, from your point of view, what are some of the things that you're gonna recommend people to look at that maybe they haven't before? Obviously, we all know microbiome is one of the biggest ones for you.

So as you know, JJ, uh, just doing things the way people have been doing it for the last many decades does not work, or it yields temporary outcomes.

Such things as exercise more, move more, eat less, reduce your calories, push the plate away [laughs].

All the things that people thought.

And at first, right, at first blush, these things sound like they're, they're effective.

They're not.

They're temporary solutions.

So why don't you talk a little bit about some of the sessions you're gonna be presenting on the cruise and in this program?

So Dr. Davis, from your point of view, what are some of the things that you're going to recommend people to look at that maybe they haven't before? Obviously, we all know microbiome is one of the biggest ones for you.

So as you know, JJ, just doing things the way people have been doing it for the last many decades does not work, or it yields temporary outcomes.

Such things as exercise more, move more, eat less, reduce your calories, push the plate away, all the things that people thought.

And at first, right, at first blush, these things sound like they're effective.

They're not.

They're temporary solutions.

They're not long-term.

So why don't you talk a little bit about some of the sessions you're going to be presenting on the cruise and in this program?

This is fascinating.

Unfortunately, the path that causes coronary disease, there are many things that cause coronary, that is heart attack, bypass surge, sudden cardiac death, all that stuff.

There's a number of factors, but one very, very fundamental factor is this very simple pathway.

You feed your liver carbohydrates and sugars.

Carbohydrate like the amylopectin A of grains.

So not gluten, but the amylopectin A of grains.

So grains and sugars, you ingest them because you were told to by the federal government and dietary guidelines.

Yeah, yeah.

What actually happened? In your career that made you say, you know what, I think I need to take a better deep look at this because what I'm doing in traditional cardiology just isn't working.

Well, as you point out, Steve, I was doing those procedures morning till night.

And then I got the call that my mom had died of sudden cardiac death just a few months after her successful coronary angioplasty.

In other words, it really struck me that the way I manage this disease, like many of my colleagues, in a cath lab was incredibly inadequate.

People die at home.

People die en route in the ambulance or in the car.

And so waiting for catastrophe to happen is a very – it's like calling the fire department when the house is almost completely burned down.

What do you have to say about that? I mean, is it bigger than just gluten or what else do you see with that?

talking about Ozembic, right?

Like Ozembic, all those things.

Those are selective for fat beneath the skin.

Not the fat in your abdomen.

And that's a problem because the most problematic form of fat, as you know, is the abdominal fat.

And of course, GLP-1 agonists lead to loss of muscle, huge losses of muscle.

And we know, we know with excellent long-term evidence.

Kind of just describe what you did to grow this.

Mm-hmm.

You know, this is catastrophic.

I have a friend, for instance, who had five pregnancies, lost all five at about two or three months.

I mean, catastrophic emotionally.

Why would this happen? Well, if we believe the evidence in this one Italian study, for instance, women who have miscarriage have much higher rates, much higher levels of lipopolysaccharide endotoxemia.

That is the breakdown products of fecal microbes in their, uh, bloodstream.

And if you obtain some of the endometrial fluid, so pelvicalyx and endometrial fluid, much higher levels of lipopoly- of these microbial byproducts from the GI tract, and much higher levels of inflammatory mediators like various interleukins and, uh, tumor necrosis factor alpha.

Yep

[laughs]

A trillion dollars from this corrupt, perverse class of drugs that does almost nothing.

Yet my colleagues, primary care cardiologists say, [gasps] "You must take Lipitor.

You must take Zocor, Simvastatin, PS- PCSK9 inhibitors." This is nonsense.

The real tragedy, of course, is the attention paid to those things took everybody's attention away from the real factors that cause heart disease, which are easy to identify, Natalie, and easy to correct.

You can do it in your kitchen.

It does not require a drug.

Mm-hmm

Now, in your book, you talk about like this relationship between oxytocin and muscle mass, which I found really interesting.

I'm uncertain.

So I, I got real excited when the animal evidence and now several other lines of e-exploration, a group at University of Texas, Dallas, Jim Versalovic's group.

There's a Cincinnati group that showed, uh, with rhoderi, with, uh, with, uh, restoration of rhoderi, a microbe that virtually all of us have lost in the modern world.

Very interesting microbe.

So if we were to sample the gastrointestinal microbiomes of, uh, rabbits, of dogs, of moose, of zebras, of gophers, they all have lactobacillus rhoderi.

If we were to study the microbiomes of people living in the savannas of Africa, Tanzania, the jungles of South America, Brazilian rainforest, for instance, or the highland jungles of New Guinea, they all have rhoderi.

Now, with this yogurt not yogurt, um, is this something people can make at home? Is this something they can purchase? How do you go about doing that?

Is that gonna help?

So I fear, Rena, I fear that probiotics, people often think are the solution.

They're not.

Let me tell you how probiotics are formulated, 'cause I formulate probiotics.

Uh, you say something like this, "Oh, well, I think, uh, Lactobacillus acidophilus is good." Throw that in.

"Oh, I think Bifidobacterium longum is good." Throw that in.

"How about some, um, Bifidobacterium, uh, infantis?" Throw that in.

Uh, but you as a cardiologist, you're saying, "No, look at your gut microbiome, and that is so important to fix your heart." So if somebody has high LDL, does that, can that be related to poor gut microbiome?

everywhere.

Now, if it's everywhere, and someone says this, this is a very common situation.

Someone would say, okay, I did your program.

No wheat, no grains, no sugars.

I did basic nutrients, addressed basic nutrient deficiencies because of the quirks of modern life, like vitamin D.

We don't live outside.

We wear clothes.

Yeah.

And so when people are looking to significantly reduce visceral fat and to change their health dramatically, what types of shifts do you recommend people make from a nutrition standpoint, from an exercise standpoint, from a lifestyle standpoint?

So one thing we never do is reduce calorie intake.

Reducing calorie intake is very dangerous for all the reasons we talked about.

It does work at first, but then it sets landmines for you.

Reduction in basal metabolic rate, loss of muscle, inevitable regain of fat, not muscle, disability, loss of independence later in life, earlier death.

I mean, it's really sobering to know how dangerous, how bad the last half century of dietary advice has been.

Thankfully, we have science to tell us, oh, there are better ways to do this.

For licenses, see homedepot.com slash license numbers.

So, uh, from your perspective, when you look back at the last year, what was the most important initiative that you led? What did you do, and what were the results?

Man, that's a, that's a big question.

Uh, it's a great question.

Couple of things I, I will point out, and I...

this won't hit everything, so I apologize to my team if I, if I do leave some of the things off.

But I- I'll tell you, some of the big things that we are very proud of, um, really, uh, centered around on expanding access to care here in Southern Illinois, and I'll say the, the results were very real, and they were very local.

So one of the major milestones that we launched was our, our neuroscience services, uh, which we did not have here, uh, in, in Marion.

I, I guess how are you continuing to bring in those folks and attract them? Um, anything that is on the cusp for this coming year?