How do you think about plasticity and what are the major phenotypes you're observing here in this data set?

I think of plasticity as the ability of a T cell to just adjust its identity and function in response to its environment.

To our students, we often teach T cell types as like fixed job descriptions, if you will, where there's a one type that promotes inflammation and another that suppresses it.

But actually, like in real tissue, particularly during chronic inflammation, the boundaries are much less rigid, like cells can share features of several programs or move into related states.

So in our study in inflamed IBD tissue, we saw a strong expansion of activated memory CD4 T cells.

And one subset had TH1, TH17-like inflammatory program.

And these also included cells with tissue resident features.

And so what do you think this means for potential self-regulation of the cell subsets?