So let's first talk about what does this mean, gut permeability? How is it measured and why it matters? And then I guess we should leave alone why the mainstream doesn't really pay attention to it.

Well, I can answer all of the above.

Like, I think that the reason, you know, you'll meet two kinds of gastroenterologists.

One, which are the neuro gastroenterologists will be like, of course, increased intestinal permeability is real.

And we've been studying this and there's these studies that I'll tell you about.

But you'll also meet a lot of gastroenterologists who are so wary.

of the misinformation around the term leaky gut on social media, that they're like, leaky gut's not real.

And if you can, maybe reveal how one could assess gut permeability in a clinical setting.

What's the game plan? What should I be putting on my plate?

Yes.

Well, okay, I will say it all depends on your goals here, okay? So there's, like, one group of people who are, will say, "Thanksgiving Day, I'm gonna eat what I want, in the quantities that I want, and don't get in my way." And to those people I say-You know what? It's a holiday, enjoy yourself, live your best life.

If your goal is to not feel ill afterwards, which is, like, common to all of us, then what I would say is to put an appropriate amount of vegetables and protein on your plate and eat those things first.

And by appropriate amount, I mean at least half the plate should be filled with those things.

In real life, we usually want to center the protein and the veggies on the plate and, like, the carbohydrate is, like, a fourth of that plate.

You don't have to go so hardcore, but at least half of it.

How does drinking on Thanksgiving affect how you feel after that meal?

You know, for anyone listening, what are the gut symptoms that you would want people to just be really finely a- attuned to, whether it's an early sign of, of Parkinson's or, um, colorectal cancer, you know, both of which we've touched on, and, and other kind of things that maybe we haven't talked about yet?

Yeah, let ...

Thank you for asking this.

So let me tell you the big ones.

So any kind of rectal bleeding, you should talk to your doctor sooner rather than later.

Rectal bleeding can be a lot of things we don't have to overly worry about, like hemorrhoids, for example.

But they're the most, one of the most important signs of early-onset colorectal cancer.

What reflections do you have about inflammation? Kind of what does the science tell you? How does this relate to the conversation we were just having about the microbiome and how does it maybe not connect at all?