excellent no that's good and now there's a uh about two or three more things we have there one of the things that comes up again on a somewhat regular basis is that is uh black bladder whether you got a full bladder versus empty now that did make a bit of a difference right tony

Yeah, this study was actually really interesting.

It was quite well done.

And they did a lot to... ensure that really everything else about the condition was equal between the conditions.

So this was 172 women.

It was just women.

And they actually ensured that they had an ultrasound confirmed full bladder.

Now you also sort of gave some, Antonio, maybe you want to comment on this, that the, you know, a five millimeter reduction in systolic blood pressure, what actually that means from a cardiovascular event perspective?

just to put in, so if you look at the pure definition, you would say that this is primary prevention, but there is a huge but here.

Yeah, there's a huge but, and what do they say? Nothing matters before the but.

So they had coronary artery disease, cerebrovascular artery disease, or peripheral artery disease.

And there was all sorts of examples they gave of what qualified for those three diseases in terms of their classification.

So someone who had a prior coronary revascularization would be included.

Someone who had a TIA would be included.

Someone with significant peripheral vascular disease would be included.

So that does make a difference.