
Tobias Moser
Neuroscientist
2
APPEARANCES
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Jul 29, 2026
Propionic acid in Multiple Sclerosis: could a short chain fatty acid improve neuroinflammation and neurodegeneration?
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Xin Yu TaiHOST
Could you tell us what led you and the field to suspect that this humble short-chain fatty acid might matter, might have an impact in multiple sclerosis?

Tobias MoserGUEST
Actually, the idea evolved in 2020 when I read a paper published in, in the journal Cell by a German, um, study group where they evaluated propionic acid in, in MS, and they found that propionic acid could rebalance and reshape the immunological dysfunctions in multiple sclerosis, as propionic acid appears to reduce TH17 cell functions while augmenting capacity of regulatory T cells.

Tobias MoserGUEST
And in addition to these very important and interesting immunological findings, they also observed clinical improvements and potential improvements on brain atrophy.

Tobias MoserGUEST
But this was just an observational study and partly retrospective, so I really thought it was about time to do a clinical trial, a prospective randomized double-blind controlled trial.
8 MINS LATER

Tobias MoserGUEST
So which on the other hand tells us that NfL is a good parameter to measure disease activity.

Tobias MoserGUEST
So w- we included 101 patients, and some of them had switched immunotherapies within 12 months.
'Shareholding as a service' in Germany
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Tobias MoserGUEST
Uh, the first is that, uh, the Nordic market is an established market with a, a, actually worldwide, um, investor base.

Tobias MoserGUEST
So you're not limited to, uh, German investors, but you can also approach, uh, investors in Scandinavia where there's a long tradition also of capital market instruments as an investment, um, but also American, um, uh, funds and other investors.

Tobias MoserGUEST
And specifically for the German market, I believe many German companies do it because the, there has been, um, a lot of bond issuance in the German mid-cap segment over the last decade or two decades, uh, basically since two thousand and nine when the German Bond Act came into place.
6 MINS LATER

Elias LambrianosHOST
So do they get their fees as a percentage of recoveries, or how exactly does it work?
