Tim O'Leary
Professor of Information Engineering and Neuroscience at the University of Cambridge, studying neuronal identity, representational drift, and control systems in the brain.
1
APPEARANCES
1
PODCASTS
Jun 20, 2026
Tim O'LearyGUEST
... broadly speaking, the, the, the genome of a cell, um, is, is decorated with all kinds of, uh, additional molecules like methyl groups and so on.
Tim O'LearyGUEST
Uh, and in the case of, um, uh, like a, a mammalian cell, um, the chromatin, uh, around DNA is also, uh, modified.
Tim O'LearyGUEST
And what this does is it makes certain genes accessible or inaccessible, um, and it can really have the, the effect of completely shutting down, uh, a subset of genes.
Tim O'LearyGUEST
So you can have a cell which has the same genome but have very different, um, modification of its genome that makes certain genes usable or not.
Tim O'LearyGUEST
Um, and then on top of that, um, you can have different splice variants and so on of, of the genes that are actually turned into RNA, and those can be modified and acted on.