Wondering if you could comment on the article by Schlaman et al.

Yes.

The emergence of radiotherapy as a potential non-invasive treatment option for osteoarthritis is explored in this review by Dr. Schlaman, Yu, and Ruhle, which they've entitled Low-Dose Radiotherapy for Osteoarthritis, Current Evidence, Practical Recommendations, and Future Perspectives.

While conservative management such as physiotherapy, non-steroidal anti-inflammatory agents, and intra-articular injections continue to form the mainstay of treatment, a significant proportion of patients, particularly elderly individuals or those unaffit for surgery, remain symptomatic.

Because osteoarthritis is a widespread degenerative joint disease with increasing prevalence in aging populations, the potential for benefit with radiotherapy for selected patients is important and worthy of careful clinical investigation.

Osteoarthritis is characterized not only by age and use-related cartilage degeneration, but also by the involvement of pro-inflammatory mechanisms.

It's this inflammatory component which provides the rationale for exploring low-dose radiotherapy as a potential therapeutic option.

I'm wondering, Dr. Delaney, if you might comment on some of these novel uses of radiation in the heart.