But in terms of a general approach to someone with atopic dermatitis, how do you start to think through how intensive a therapy does this person need and when would you potentially advance their therapy?

It's partially based on symptoms and how much is affecting the patient and also total body surface area involvement.

We usually say that if you have less than 10% total body surface area involvement, then you can usually get away with topical therapy.

But once you get above 10%, it becomes a little bit more onerous, a little bit more difficult to do topical therapy reliably.

And then I would say, as I said, the other part is how much it's affecting a patient.

So for instance, a patient can have very little body surface area involvement, but have involvement on the face or have involvement in the hands where it's affecting function, affecting, you know, their quality of life.

And we might be more aggressive with therapy in that perspective.

How do you counsel them about how to use those?