Why has this remained such an uncertain space?

Because the concern is legitimate on its face.

Uh, portal hypertension, coagulopathy, esophageal varices, these are all real considerations when you're creating a submucosal tunnel and cutting the muscles.

The worry has always been that you could trigger a variceal bleeding or hepatic decompensation.

But here's the problem: cirrhotic patients are not protected from developing achalasia or esophageal motility disorders.

And when they do develop them, clinicians often, um, default to Botox, a very short-term palliative measure which does not provide definitive treatment.

And, uh, and the reason is that the definitive treatment like myotomy is felt to be too risky.

Do you think our findings shift that?