Dr. Stahl, I'm curious your thoughts here.

Well, um, I, I think that we don't know when somebody is responding, whether that needs to go forever.

Um, long-term trials don't exist.

You know, registration trials tend to be, you know, a few weeks to a few months, sometimes a year.

But, you know, being able to show that sustained remission is due to the presence of the drug is, is not well established.

And so the question is, have the receptors done whatever they need to do to sustain- They're, uh, they're, uh, they're good parts.

I mean, probably receptor adaptations occur for the good parts of why the medicines do work, and then of course, there's the off-target things, um, uh, and, and it-- which actually you don't want, but are part and parcel of the drug's action.

What about sedative hypnotics? You know, let's say the Z drugs or even, uh, etrazodone or something like that.