Tell us what we know about how repeat expansions in a single neuron can impact how long it takes for Huntington's disease to manifest.

In Huntington's disease, we think it takes many decades for this CAG repeat to expand from the length at which it's inherited, typically 40 to 60 CAGs, to the length at which it becomes toxic, which we estimate is about 150 CAGs.

And what are ways that we could leverage that knowledge to impact therapeutic advances in HD or other expansion diseases?

Our own cellular enzymes are complicit in somatic expansion.

This is work that's been done by Vanessa Wheeler and Ricardo Morapinto and others.

And one of the implications of that is that some of those enzymes may be suitable targets for future medicine.

So it's kind of a lively area right now in drug discovery.

to identify molecules that slow the function of those enzymes with the hope that by doing that you might be able to kind of slow this ticking DNA clock.