Please tell us how ADCs are manufactured to target and kill cancer cells while avoiding healthy cells and organs.

Thank you very much, Professor Matlon, for this excellent introduction.

I'm very grateful to have been given the opportunity to contribute an article to your excellent journal.

And I'm really delighted to be here to join you all.

The basic principles of an antibody drug conjugate, being a very highly engineered therapeutic, is the three components it's made up of.

A monoclonal antibody that recognizes a tumor associated antigen.

which is normally a cell surface antigen expressed or protein expressed on a cancer cell, but not necessarily all the time, most of the time, a potent serotoxic payload and a chemical linker that brings these components together.

Does ADC-bound doxorubicin minimize the side effects? Is it equally effective? as for example doxorubicin liposomes of free doxorubicin.