
Sean Mackey
American scientist and anesthesiologist
2
APPEARANCES
2
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012
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Aug 5, 2026
Fibromyalgia Explained: Causes & Treatments
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9:24MikeHOST
So what causes fibromyalgia? Why do so many people develop it?
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9:43Sean MackeyGUEST
We know it's a threshold condition, meaning that your genetic makeup probably loads the gun.
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9:52Sean MackeyGUEST
It runs in families, pain processing genes do matter, but probably not a huge amount, but it matters.
18 MINS LATER
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28:23MikeHOST
So what treatments tend to work best for most people?
Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.
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3:57
4:11
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4:28
Peter AttiaHOST
So if you were trying to explain to a Martian from another planet who doesn't experience pain what it is, what would you say?

Sean MackeyGUEST
There's the formal definition of pain, which is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage.

Sean MackeyGUEST
If you think of it as it's an unpleasant sensory and emotional experience, it's usually tied to something physically happening, but may not be.

Sean MackeyGUEST
I think sometimes what's missing in that definition, one of the things I wish they had put in but never did, is that pain is the great motivator.

Sean MackeyGUEST
Pain is one of the most primitive experiences going back to, if you will, single-cell organisms.
36 MINS LATER