Just educate our audience again a little bit regarding pressor choice, first-line, and then subsequent use of other pressors.

Yeah, thanks for that.

So there's two randomized controlled trials in pediatrics that compared dopamine to epinephrine head-to-head in septic shock, and both showed mortality benefit for use of epinephrine.

Now, there were maybe some arguably differences in titration strategies, but really they reflected the way we use those medications in clinical practice.

So the clinical use of dopamine seems to be inferior to the clinical use of epinephrine.

And so those studies really changed the recommendations from dopamine first to more of a epinephrine first strategy.

Now, in the adult guidelines, norepinephrine is generally preferred.

High-level summary, where are we with biomarkers today?