[laughs]

That normally when you think of an infectious disease, you think of some foreign entity getting into your body, like a, a virus or a bacteria, but this is a part of your own body that turns against you, that you have this one protein and absolutely all, all mammals, all vertebrates have it, that exists within your brain and within your nervous system of this polypeptide chain that folds up into one particular pattern, like folding a piece of paper into a paper airplane allows it to fly.

But that same piece of paper, you could fold it up into an origami swan, and all of a sudden it takes on different characteristics, and that's what happens here, is that this, this protein just refolds itself into a form that's both pathological as well as self-propagating.

So it's not some foreign thing that's attacking you.

It, it's your own body turning against you.

And so in some ways it's almost more, you know, like a cancer than it is a traditional infectious disease.

But it brings in the same issues you have when trying to treat cancer, of how do you target the cancerous cells while leaving the healthy cells alone to minimize the consequences? How do you achieve that specificity that you can tell apart the healthy and unhealthy forms of the protein? A- and that's really been the foundation of our approach, is targeting regions of the protein that are only exposed for antibody binding in the misfolded form.

Yeah