As an anesthesiologist and an intensivist, where do you feel it most acutely? Is it at the point of intubation, or is it in the maintenance phase for our patients?

I would say both.

The most obvious profound effect is, you know, within fifteen minutes of the drug given, and that's usually during the intubation phase.

That's somewhat obscured by when you do intubate somebody, you have this sympathetic response to the laryngoscope blade, whether it's a video laryngoscopy or a direct laryngoscopy.

So you kinda have a, a counterbalance, if you will, to the hypotension that propofol could cause.

But that counterbalance is not even, rarely is it actually ever even.

And so oftentimes what you see is more of the hypotension than really any hypertension, if you will.

So, Scott, before we get too much down the line with other questions, I wondered if you could go over the propofol infusion syndrome and what our clinicians should be worried about with that condition.