Does it matter in brain health? Like these delineations we're making or these shifts and transitions in life, Sarah, does it actually have a bearing when you are studying the brain specifically?

Absolutely.

I mean, there's so much physiological change that happens in a woman's body when they approach the perimenopausal period.

And so much of what they do in response to that will dictate how they age and how their brains age.

when we think about the impact of changes in estrogen on blood pressure, on vascular health, when we think about how well we sleep and how vasomotor symptoms of perimenopause impact our sleep, which then impacts our clearance of really important bad proteins from our brain.

There's so many interventions that can happen that are at this critical period that really set the stage for what our brain is going to and how our brain is going to approach aging and how well it's going to do.

And the better we understand it, the more we meet women where they're at, and the more that we're able to, as Sheila mentioned, really take charge of that opportunity, the better we'll be able to do in terms of healthy aging for women and their brains.

That's my take on it.