interfering with placental development.

But aspirin is also anti-inflammatory and it has these anti-inflammatory effects as well.

And we know that inflammatory pathways also contribute to preeclampsia and preterm birth.

And so we don't know is it, which pathway that aspirin is working in, is it one or the other or both together that is related to its effect that we see in reducing the risk of preeclampsia and preterm birth.

And so just our lack of understanding first of the disease process itself and then second of what exactly aspirin is doing to prevent that disease process.

Those are the reasons there's still so many questions in the air about what aspirin is doing to prevent preeclampsia and preterm birth and how we might be able to use it better.

And the final gap that we have in our knowledge that's preventing our optimal use of aspirin is that for a long time, we've been using aspirin in pregnancy, the same way that we've been using it in non-pregnant adults, that low dose aspirin that's recommended 81 milligrams.

So the big question, Roopsha, is why is it that women who have higher BMI or women that have diabetes before getting pregnant would not benefit from aspirin? What's happening with their blood or blood volume that is different from women that don't have those conditions that prevents aspirin from working as it should?