But this is probably something which is very interesting and I think it really got attention when the LYRIQ trial came out and now we are at the 10-year level of the lyric trial so perhaps you can explain a little bit the background and your opinion on this as a surgeon

Fantastic.

So the Lyric trial is a very brave trial.

It took long to recruit because, of course, randomization between surgery and medical therapy is not something we see every day.

So it took seven years to complete the recruitment for the Lyric trial.

So it was a very brave trial.

And I think that if they did the protocol today, they would do patient preference trial because it makes more sense.

For me as a gastroenterologist doing an appendectomy on a very healthy patient, must be somehow a high risk patient, seems still a little bit strange and The background, at least the immunological background, is probably there, but I would like to learn about your opinion on this very exciting area of research.