Why does it matter delaying when you start insulin?

Just to remind you that teplizumab is a 14-day course.

You don't take it forever.

So it's a, it's a short course, whereas insulin, you start and you, you carry on long term.

If you talk to people who live with type 1 diabetes, a day without insulin, it would be amazing, let alone two years.

You're constantly adjusting the insulin doses according to what's going on in your day, whether you're well, whether you're unwell, whether you're doing exercise, whether you're sitting at a desk, how much food you're taking.

And if you get it slightly wrong, then it has a profound effect, not just on mood and energy levels, but potentially also on the risk of long-term complications.

And Parth, what is teplizumab actually doing inside the body?