Who is likely to convert to MS and when? Over to you, Olga, to maybe discuss some aspects around the study.

Yes, that's right.

So the LIM study in JAMA Neurology involves patients studied in three academic centers, as you said.

They divided the group of patients into a discovery cohort, which were the participants studied in Toronto, and a validation cohort which included participants studied at NIH and in Buenos Aires.

And these were participants who were included at the time they were diagnosed with the radiological isolated syndrome, as you explained, where this incidental finding of MRI lesions, typical for MS, and participants were followed up over time in these three centers.

These radiological isolated syndrome participants were studied with MRI and clinical assessment at the study entry and then followed up prospectively over time.

And the diagnosis of MS was given according to 2017 diagnostic criteria.

And there's been quite a few studies showing that these rim lesions are a marker of progression, which of course makes perfect sense.