So it's like this kind of, um, self-stimulation and stimulating these other areas that trigger hot flashes, and that's what happens.

There's two parts of hot flashes that are really sort of mysterious and still remain to be understood, and, uh, how does the brain adapt? I mean, we know the brain adapts to so many things.

It's what makes us human.

So the brain does eventually adapt for 85 to 90% of women, and there's this 5 to 10% that their hot flashes never go away, and they're just as bad as they were in the menopause transition.

The other part of this that's also very fascinating is that we think of hot flashes in association with low estrogen, but during the menopause transition, estrogen is up, it's down, it's up, it's down, it's variable, and that is when hot flashes peak in a woman's life.

So that's when they, they reach their highest level then and the year or so after the final menstrual period.

So why they're still happening with full force when estrogen is there is also not known, so there's something more dynamic going on.

What has changed?