Mona Kumar
Monisha ("Mona") Kumar, MD, is a neurointensivist and Professor of Neurology at the University of Pennsylvania, where she is Vice Chair of Quality and Safety for Neurology and Director of the Neuro ICU.
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APPEARANCES
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PODCASTS
Sep 30, 2026
Eric LawsonHOST
Can you all discuss some of the differences in the methodology employed? Maybe touch on some of those five main questions you use to guide the review and what makes this study group a little more unique?
Mona KumarGUEST
The methodological shift between the 2016 guideline and the 2026 guidelines is actually pretty substantial.
Mona KumarGUEST
There were differences in evidence rating, risk of bias assessments, decision framework, panel structure, as you alluded to, and literature search.
Mona KumarGUEST
The 2016 guidelines did apply grade methodology, but back then there were no pooled meta-analyses.
Mona KumarGUEST
The case series threshold was greater than five patients, and that's just because there was a paucity of data at the time.