So what have you been trying to focus on in your research to work out what's underlying this?

Well, if I went back a long time, My background was the fetal origins of adult diseases and we used sheep as models for that and that tended to be very metabolically based looking at the development of various metabolism systems and so having also a background in the ovary I was really really delighted to combine both and start working with Colin.

However, In all those years, I've never got the chance to work on an ovary.

Because, and actually this is why I like the new name, in our work with sheep where we recreate PCOS or PMOS in the sheep, we've worked on the pancreas, we've worked on the liver, we've worked on the adrenal, all basically the powerhouses of metabolism.

And really I guess what I think we've managed to do in a small way is integrate various metabolic organs like the ones I've just mentioned with the reproductive system and to some degree I guess the fertility, the reproductive parts of PNLS, at least some of them, may actually be victims of the altered metabolism.

But for me personally, just the opportunity to have a clinically relevant paradigm to work in that shows how the early life experience configure our health trajectory to some extent or another for the rest of our lives has just been fantastic

so what kind of has been your most interesting or what findings have you thought wow like that's changed how we think about things particularly when it comes to the fetal origins of pmos

whether it's changed how anyone else thinks about things i have no idea but um For me, the whole story of insulin resistance developing and so if your insulin isn't doing its job particularly well to tell cells of your body to uptake glucose that's been absorbed from your gut, then you need more insulin to get your glucose concentration correct.