To dive into the background of this paper, what did we know about hypercapnia and right ventricular function before this study?

Sure.

So the partial pressure of carbon dioxide in the blood, as probably most of your listeners know, is the balance between the elimination and the production of carbon dioxide.

And in most cases, in clinical settings, we usually think as the partial pressure of carbon dioxide as the rate of elimination and hypoventilation causes hypercapnia.

And it's important to note, I think, that there's been a marked increase in the incidence of hypercapnia among critically ill patients, especially undergoing mechanical ventilation.

And this is probably in large part due to permissive hypercapnia as part of ARDS treatment.

And hypercapnic acidosis, as of course follows, hypercapnia acidosis follows.

So now that we kind of have this background for the study and sort of some of the key elements of it, could you could you all give us a basic overview of the study design?