And I wonder, you know, how do we shape that future state where we think about these along the same spectrum?

Indeed, uh, there are several aspects that should be considered.

For example, you mentioned timing.

For what concern the antibiotic therapy, antimicrobial therapy administration, we do have precise situation very well described.

For instance, the discriminant is the shock is present or is absent.

When the sepsis is definite or probable, or in presence or not of shock, in this case, you have to administer the antimicrobial therapy immediately, a- and if possible, within one hour of recognition.This is also true when the sepsis is possible, but the shock is present.

For what concern the possibility when the sepsis is only possible and the shock is absent, this is the only condition where the rapid assessment of infections may help us, and the administration of the therapy can be within-- a, a bit postponed, uh, within three hours.

So this is where, you know, I think it was very helpful having this global panel and, you know, being able to do these panel surveys and sort of just understanding the heterogeneity and the sort of resource availability and the context by which people practice.