So that then begs the question of what are the downsides of epi, because obviously more is not always better.

Yeah, exactly.

There are some animal studies and large animal models that suggest impaired cerebral blood flow at the microcirculatory level, even though at the macrocirculatory level, there's evidence that it in fact improves cerebral blood flow.

So I think that's not fully hashed out.

Additionally, there's arrhythmia risk with any high dose of catecholamines and then diastolic dysfunction as well.

But a question for you, Cameron, as the adult CCM doc.

There's some adult retrospective data that shows that higher epifrequency measured in milligrams per minute was associated with lower rates of survival with an odds ratio of 0.05, as well as lower odds of favorable neurologic outcome at discharge with an odds ratio of 0.02.

I mean, what is the kind of background of more frequent epidosing at CHOP, and why is it that you guys think that might be a good idea?