Um, so today, again, we're gonna work through the pathology, the terminology, and, um, kind of that tricky scenario of what exactly a basosquamous cell carcinoma is, and what we should be looking for when we encounter one of these tumors on our Mohs slides.

Hi, I'm Marina Ibrahim.

I'll be reviewing Basosquamous Carcinoma by Garcia et al.

from the Journal of the American Academy of Dermatology, published in two thousand and nine.

As a concept, basosquamous carcinoma is not really well defined.

Initial definitions for this tumor suggested that it served the spectrum between basal cell carcinoma or BCC and squamous cell carcinoma or SCC.

Though with time, this term came to refer to a very particular type of tumor.

Thank you.

Hi, I'm Marina Ibrahim.

I'll be reviewing a clinical and biological review of keratoacanthoma by Tissek et al.

from the British Journal of Dermatology, published in 2021. keratoacanthoma or KA, and squamous cell carcinoma or SCC, often are difficult to distinguish from each other clinically and microscopically.

Distinguishing between these two entities is of importance as their biological behaviors are dissimilar.

SCC, which comprises up to 50% of all cutaneous malignancies, is associated with UV exposure, immunosuppression, HPV infection, long-standing wounds, and immunotherapy exposure.

SCC metastasizes in 4-6% of patients, but if high-risk sites are involved like the ear or the lip, the rate may leap up to as high as 30%.