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M. Scott Perry

Oct 30, 2026

0:57
obviously dr perry epilepsy trial design has you know evolved and changed a lot over the last decade or so so where do we think we are right now and what's been the biggest shift in how we approach these studies
1:10
You know, I mean, there's been a lot of things that have changed in trials.
1:13
I think one of the more recent things that we're seeing is the use of basket trial design.
1:20
So this concept that, you know, a lot of anti-seizure meds are just that, the kind of anti-seizure meds, they're not specific necessarily to any one etiology.
1:31
So instead of grouping, you know, a trial around a single syndrome, you could take several syndromes that are kind of similar, right? So take multiple developmental and epileptic encephalopathies.
1:43
And as long as the medicine doesn't have some specific precision reason to be better for one than the other, why not group them together and study them as a group? And then maybe within the group, in the trial, you'll see some do better than others.
1:56
But just a way to kind of really... examine more epilepsies at one time.
3:35
So what other outcomes do you think deserve more attention that should kind of be propped up for primary or secondary endpoints in these trials?

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