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Logan Thrasher Collins

Logan Thrasher Collins

PhD candidate in biomedical engineering at Washington University in St. Louis; co-founder of Cathedral Therapeutics (acquired by General Cybernetics, 2025); expert in gene therapy delivery systems and synthetic biology.

Jul 5, 2026

15:28
Uh, talk, talk to us a little bit about, you know, what are protein vaults? And then we can go back and just, you know, talk about the ancestry of the entire delivery space as well.
15:39
Sure, sure.
15:39
So I, I should say that I, I'm the inventor of, uh, specifically protein vaults for delivery of viruses, um, and just to sort of clarify that first.
15:50
But as to what protein vaults are, um, so protein vaults are a mysterious organelle.
15:57
They're composed of 78 copy of a protein called major vault protein.
16:00
They look like, uh, two cups stuck together that have sort of a specific structure, and these cups, uh, are kind of...
16:07
They're, they're very nice.

5 MINS LATER

21:17
Um, talk to us about what was the v- like the first delivery, uh, mechanism that you were aware of and, and, uh, what was the-- Yeah, how, how did the field sort of progress since then?

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