
Liam Fedus
Computer scientist
5
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Oct 8, 2026
Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk
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Liam FedusGUEST
Uh, our data comes from our physical labs, and this is sort of our ultimate truth.

Liam FedusGUEST
It's not enough just to do optimization against, um, some answers that were known in some papers or textbooks, because we're going beyond that, and I think that's one of the biggest differences.

Liam FedusGUEST
So when you're doing optimization against math, there's a, a high precision to it.

Liam FedusGUEST
You're not really dealing with, you know, kinda like variance or uncertainties or, you know, aberrant measurements, whereas that's very key to, to our process.

Liam FedusGUEST
Like, um, for example, when we are doing materials discovery loop, things don't come off the, out of the furnace labeled, right? Even the labeling process can be stochastic and noisy.
1 HR 11 MINS LATER
S
75:06SwyxHOST
Yeah
Liam Fedus - Co-Founder of Periodic Labs
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Brendan FoodyHOST
And talk a little bit more about why you chose to start Periodic and what you guys are building.

Liam FedusGUEST
One of the biggest objectives, I think, for this technology is to start changing the course and trajectory and speed of science.

Liam FedusGUEST
If we can start building up new knowledge, not just sort of, um, resurfacing and, um, recombining existing knowledge, but really like pushing the frontier, this would lead to just a huge acceleration and overall productivity, um, gives us agency to kinda begin to construct and do things in our physical world.

Liam FedusGUEST
But I felt in order to do this, it was necessary to connect to the physical world.
A chatbot walks into a laboratory
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Liam FedusGUEST
And so in college, I was actually a bit between physics, chemistry, economics, and I was part of a dark matter detection program.

Liam FedusGUEST
And one of the key pieces for that was reconstructing the particle tracks, which became like a physics model.
21 MINS LATER
Is Canada ALL IN on A.I.?
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Liam FedusGUEST
Mid-training allows you to inject some of your, um, company's knowledge or know-how that may not be in the existing model.

Liam FedusGUEST
And so basically, how do you internalize that? And this is something you can do in addition to just giving a search or rag.

Liam FedusGUEST
It's basically the difference of an employee showing up and having to figure things out on the fly versus they've already kind of internalized some of the knowledge.

Liam FedusGUEST
So given those three pieces, we now have agents where we can start with a, a model.
Building an AI Physicist: ChatGPT Co-Creator’s Next Venture
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Liam FedusGUEST
So ChatGPT originally, the technology evolved very rapidly over the last few years.

Liam FedusGUEST
And what you're trying to do is take this auto-completion model and turn it into something useful.
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