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Leonard Zon

Leonard Zon

Leonard I. Zon is the Grousbeck Professor of Pediatric Medicine at Harvard Medical School and Director of the Stem Cell Program at Boston Children's Hospital, known for using zebrafish to study human disease.

Mar 25, 2026

15:53
And tell me how this lipid does this in zebrafish and in humans.
15:57
Yeah.
15:57
So in the early 2000s, we developed a strong interest in stem cells.
16:03
And Using the zebrafish, we could actually mark the stem cells with specific genes, one gene called RUNX1 and another gene called C-MIB.
16:14
And one of my postdoctoral fellows, Trista North, discussed doing a chemical screen where you add chemicals to the water and see if you could ever find a chemical that would increase the number of blood stem cells by staining with RUNX1 and C-MIB.
16:30
Now, the number of stem cells that is transplanted in a human correlates to the success of the transplant.
16:37
The more you transplant, the better off the patient will be.
20:48
Tell me about these two diseases and about these two therapeutics and how promising are they?

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