
Ken Cooke
Professor of Oncology and Director of Pediatric Blood and Marrow Transplantation Program at Johns Hopkins University School of Medicine; pediatric hematology-oncology specialist focused on graft-versus-host disease prevention and treatment.
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OCT 5
Jun 18, 2026
ASTCT Talks: GVHD in Pediatrics: Acute and Chronic Risk
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9:04
9:17
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22:48

Corey CutlerHOST
So Ken, being at sort of the home of PTsi, what are people looking at both in adults and in pediatrics in terms of enhancing the immune reconstitution, which I think those of us in the adult world still recognize as being a major problem with that regimen?

Ken CookeGUEST
Uh, our data for immune reconstitution, particularly in the context of haploidentical transplants, although this has not been published, is actually quite robust.

Ken CookeGUEST
I will tell you, certainly in the context of our non-malignant disorders, we really have no issues with immune reconstitution with respect to immunoglobulin levels, with respect to CD4 recovery.

Ken CookeGUEST
And I, I am well aware of the data that have been, I, I think soon to be published by Leslie Keen and colleagues, which speak to this, quote, "bottleneck." I mean, I think that was very elegant work.

Ken CookeGUEST
I would pause and say on record that God forbid I needed a transplant, I would really want to be alive, disease-free, and GVHD-free.
13 MINS LATER

Corey CutlerHOST
So Ken, what are you excited about on the PTsi side of things in terms of novel strategies there?