But the gut microbiome, tell us more.

Yeah, very interesting, because we're learning now.

And Lisa Moscone is the other researcher.

She's in New York State, and she is studying brain images of women and connecting the cognitive decline that we see in Alzheimer's and dementia with lack of estrogen.

And she has noted that these changes in the brain occur up to 15 years before our last menstrual period.

That's paradigm shifting, right? Because previously we had said maybe five, maybe 10 years before your last menstrual period, we're thinking about perimenopause, but that physiology occurs much greater, you know, much sooner, a decade, decade and a half sooner than we're seeing the significant menstrual symptom.

With regards to perimenopause in the gut microbiome, some of the first shifts you will see based on progesterone decreasing and estrogen fluctuations is bowel movement changes.

So I'm intrigued.