So can you talk to us a little bit about the demographic and surgical characteristics that did predict success with goniotomy?

Sure.

So we looked at predictors of both short-term success, so within six months of goniotomy, and long-term outcomes, so after six months in the more than forty-eight thousand eyes, uh, like Dr. Li mentioned in the Iris Registry.

Uh, we define success as greater than or equal to twenty percent IOP reduction from baseline without clinical hypotony or need for reoperation.

So the factors that were associated with short-term success included more severe glaucoma compared to mild glaucoma, um, as well as low-tension glaucoma and pseudoexfoliation glaucoma compared to primary open-angle, um, as well as concurrent phaco, uh, was associated with short-term success and postoperative pilocarpine use, older age, male sex, and higher baseline IOP.

And our long-term outcomes were actually very similar to that, um, with the differences just being that, uh, postoperative po- pilocarpine use was no longer associated, but concurrent canaloplasty was associated with positive long-term outcomes, and smoking history and non-Hispanic Black race was associated with worse outcomes.

So a lot of these factors have been commented on previously in the literature, mostly in kind of smaller studies like we've talked about, um, but especially higher baseline IOP, concurrent phaco, since that can independently lower IOP, and also pseudoexfoliation since it can obstruct the trabecular meshworks, which are the, you know, site of the target for goniotomy.

But I think my last question would really be, what is your closing message about this study for our listeners? Clinically, how can we use this in our practice?