Joseph DeSimone
American chemist and inventor
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Jul 15, 2026
S9 Ep9: Joseph DeSimone's Big Idea: Medical Innovation through Precision Manufacturing
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2:57Lloyd MinorHOST
Can you talk some about that and how you have come to focus on some really, really important problems and challenges in biomedicine and how your previous background in polymers and other fields of manufacturing has enabled you to have particular impact in biomedicine?

Joseph DeSimoneGUEST
Yeah, so as a polymer guy at Carolina, I was at the University of North Carolina, I got approached by a professor in the School of Medicine for delivering, back then, silencing RNA.

Joseph DeSimoneGUEST
And at the time, in polymers... you know, the thing where people are using colloids, almost analogous to LNPs, lipid nanoparticles used in vaccines.

Joseph DeSimoneGUEST
So could we marry this amazingly precise molecule in medicine, nucleic acids? And the solution at the time for me and others was a cousin to paint technology.

Joseph DeSimoneGUEST
And to me, that was such a pedestrian answer to these beautiful molecules in medicine that I thought, well, why don't we bring some of the the deterministic, the precision of microelectronics manufacturing methods associated with polymers, and marry that with the drug delivery space, and related kinds of structures.

Joseph DeSimoneGUEST
So our first foray, I was approached by, to deliver siRNA as a particle, and I was also approached by a professor at Duke, an interventional cardiologist, that had a vision for a biodegradable stent.

Joseph DeSimoneGUEST
So we married these capabilities and we started a company that developed a degradable, a drug eluding degradable stent.
18 MINS LATER