Again, I'm sure our listeners will know this, but how is it that GLP-1 agonists or GLP-1 medications, if you're including Tazepatide, how is it that they're helping patients to lose weight?

So if we go back to the original basic science of this, and I was involved in some of this work back in the 1990s, what we knew at that time was that there were hormones from the gut that included both GLP-1 and GIP that are released after a meal and actually act as the main stimulus to insulin secretion after a meal.

And that led to expiration of these naturally occurring peptides as potential treatments for type 2 diabetes because they stimulate insulin secretion.

And they do that in a way that is dependent upon the prevailing glucose levels.

So they don't tend to cause hypoglycemia.

At the same time, people were also interested in some of the signaling molecules from the gut that led to people feeling fuller after meals.

And I was involved in some of that research back again in the mid 1990s, where we were able to show in experimental models that GLP-1 was actually part of that natural satiety system.

I think hair loss has been reported, and is it neon has been reported?