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John O'Donnell

VP of Global Health Economics and Outcomes Research (HEOR) at Madrigal Pharmaceuticals

Aug 2, 2026

speaker_0HOST
0:08
We hope you enjoy the program
0:12
In the early months of my life, I was frequently left out in our back garden.
0:19
To be clear, I was not simply cast out onto the grass.
0:23
Although I was their firstborn, my loving parents did not believe I possessed any of the characteristics of the Child of Prague.
0:32
Instead, I was pushed outside and parked in an elaborate four-wheeled vehicle.
0:39
Nowadays, they're referred to as buggies or strollers, but what I was lying in was definitely a pram: a sinister, high-hooded affair that would not have looked out of place in Rosemary's Baby.
0:56
This dark contraption had already attracted attention in our local park where, while wheeling me around, my mother was chatted up by Brendan Behan, who lived nearby.
2:30
And what types of issues can real-time monitoring detect that might otherwise go unnoticed?
2:37
Sure.
2:38
Everything from unexpected yield loss, say a quarter way through a wafer, which if not detected would waste tester time because maybe the fixtures need to be fixed, et cetera, by a technician.
2:50
To idle time, I have passed in my time, I'm sure any listeners who are familiar with test floors will be aware that testers aren't running all the time.
3:01
But to be able to capture when idle time happens, are there patterns involved in when idle time happens? All this is available and is possible to, first of all, detect, but also analyze if you have a real-time system.
3:18
Often lots are retested, certain bins are retested.
3:23
What if, because of real-time, the tester itself knew that there was no point in retesting certain bins because the success rate of retest is very low.

5 MINS LATER

9:01
Can it help with the concept of feed forward? Maybe you can talk a little bit about what feed forward is as well.
RuthHOST
26:56
So, John, what were you reading around then? What fiction were you reading as a young barrister?
27:02
I mean, I'm trying to think of some of the books, you know, that I remember.
27:06
There's one book that I still remember, and it is about a lawyer, but it's about the impact of what happens...
27:22
when a lawyer comes to town, it's a book called The Suite Hereafter by Russell Banks, I think it's by.
27:29
And it's a book, what happens in it is there is a school bus which crashes in Canada, I think, in the little village in Canada.
27:40
And the lawyer comes to town because there's going to be litigation, there's going to be a claim because a number of the people in the bus are killed or injured.
27:50
And look, it's obviously tragic.
RuthHOST
32:08
But is there a book like that that just marked a moment in your life?
11:25
Um, but aside from your dad as a lawyer, was there any other leadership influences before you even got into industry?
11:32
Yeah, I think, um...
11:34
Yeah, well, I, I'd have to say that that's the way my dad spoke with us, and so it, it kind of at times it's, it's been at, at times a detriment in industry because sometimes my colleagues would just say, "Hey, can you just, just don't use a, don't use a $100 word here.
11:47
Can you just spell it out?" So it's something that I actually, uh, monitor at times, but, um, uh, it sounds like a bit unsuccessfully.
11:55
Uh, but in terms of, you know, other kind of analogs for leadership, I have to say I, I have been a study.
12:01
I'm kind of a deep reader and reader of history, so, uh, maybe a little bit less lately because we're launching on a global basis, so I'm l- reading a lot of our science-based work rather than, you know, history and great leaders.
12:13
But I have made a study and, and just watching great leaders who I've admired in my careerUh, I would say, you know, historically, you know, not surprisingly, Lincoln comes to mind.

13 MINS LATER

25:50
Can you speak to that?

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