J
John Mullinax
Surgical oncologist and sarcoma specialist at Moffitt Cancer Center, focusing on tumor-infiltrating lymphocyte (TIL) immunotherapy for soft tissue sarcoma.
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OCT 5
Oct 8, 2026
TIL Therapy in Sarcoma: From Tumor Procurement to Clinical Response
8:54
27:16

Daniel OlsonHOST
You know, what did you learn in that experience of finding the sarcoma subtypes that can grow out TIL, and what's been your experience with some of the clinical experience so far as well?
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9:04John MullinaxGUEST
So as I said when I joined here, uh, ten years ago now, that at the time, the melanoma effort here at Moffitt was really in its infancy in terms of adoptive cell therapy using TIL in patients with metastatic melanoma.
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9:16John MullinaxGUEST
Prior to that, really most of the work had been done in Bethesda at the, at the surgery branch.
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9:19John MullinaxGUEST
And so Moffitt was-- had generated a cell therapy facility and was very interested in that work.
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9:24John MullinaxGUEST
So as I joined, the question was, can we make this work in some way for patients with soft tissue sarcoma? As Dr.
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9:29John MullinaxGUEST
Banks pointed out, you know, the, the, um, unmet need in terms of effective therapies is, is incredible in sarcoma.
18 MINS LATER

Daniel OlsonHOST
Can you talk about your experience at all and what's it been like, you know, to grow the program and adapt to a commercially available product with melanoma, but then also have to adapt that in research and, you know, what do you have in terms of recommendations for, for other centers who are thinking about trying to do this?