And for our audience's sake, how does targeting work when you have organ-specific, tissue-specific, and cell type-specific targeting of these reprogramming factors? What's the actual method of delivery that's

specific? Yeah, I guess there's kind of three ways of targeting.

One is very crude, but you can target by choosing where you inject something that causes those transcription factors to be expressed.

For instance, if you inject it in the eye, which I know sounds grisly, but there are these tiny little needles and lots and lots of eye injections happen these days.

very safely, then that is targeting the inside of the eye.

For the most part, it doesn't end up going all over the place and into the rest of the body.

The second would be to use vectors that only go into certain types of cells.

A lot of big generational tech companies leave this legacy of not just like the products and services that they created, but also the mafia of individuals that sort of leave that company and start their own companies and have their own significant impact and generate value for economy and for humanity, what would you hope the team at Retro will get up to after you've achieved these goals?

hmm,

we kind of got it right.

We got part of it right, but it didn't quite work.

And there's some other stuff that we didn't understand.

And then we learn more and then we can tweak our model and make a new intervention and try again.

And there's this cycle.

And it's all got, as the backdrop against it, our imperfect knowledge of biology.

I think we still haven't grasped what is happening right now and what people like yourself and Sam are doing.