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Jeff Sharman

Jeff Sharman

Hematologist-oncologist and Director of Research at Willamette Valley Cancer Institute (Eugene, Oregon); Medical Director of Hematology Research for The US Oncology Network / Sarah Cannon Research Institute.

Oct 13, 2026

21:38
"Send the paper back." Tell that story.
21:41
Yeah.
21:41
Uh, so, so Kanti Rai, um, uh, was a young, uh, clinician at the time, shows up at, um, a clinic one day, sees three patients with totally different, uh, clinical outcomes.
21:54
You know, one is like transfusion dependent, one is just on watch and wait, and one is, uh, clearly progressing.
22:01
And, um, uh, you know, he asks his mentor like, "How can this be the same disease?" And his, his, uh, uh, um, mentor sort of pats him on the back and says, "That's for you to figure out." [laughs] And so, uh, Kanti actually goes into the medical library at, at his institution and, uh, asks to review all the charts.
22:20
The medical librarian's like, "No way.
22:22
You are not getting these charts." So he actually hand transcribes I think it was like 50 or 60 charts.
24:55
I th- I thought it was a very powerful story.
7:36
So, Jeff, we're going to start out with you, if you want to go through some of these papers on first-line therapy.
7:43
Absolutely.
7:44
Thanks so much, Neil.
7:45
And I think it's a lot of slides in 10 minutes.
7:47
So let's go.
7:49
This is a long-term follow-up of the CLL14 study.
7:54
And that was a study that compared obinutuzumab venetoclax versus barambucil.

13 MINS LATER

20:45
Can you talk a little bit about it?
7:36
So, Jeff, we're going to start out with you, if you want to go through some of these papers on first-line therapy.
7:43
Absolutely.
7:44
Thanks so much, Neil.
7:45
And I think it's a lot of slides in 10 minutes.
7:47
So let's go.
7:49
This is a long-term follow-up of the CLL14 study.
7:54
And that was a study that compared obinutuzumab venetoclax versus clarambucil.

13 MINS LATER

20:45
Can you talk a little bit about it?
7:36
So, Jeff, we're going to start out with you, if you want to go through some of these papers on first-line therapy.
7:43
Absolutely.
7:44
Thanks so much, Neil.
7:45
And I think it's a lot of slides in 10 minutes.
7:47
So let's go.
7:49
This is a long-term follow-up of the CLL14 study.
7:54
And that was a study that compared obinutuzumab venetoclax versus clarambucil.

13 MINS LATER

20:45
Can you talk a little bit about it?

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