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Jason Shepherd

Neuroscientist and Professor of Neurobiology at the University of Utah, known for discovering that the memory gene Arc forms virus-like capsids that mediate intercellular RNA and tau transfer.

Sep 29, 2026

3:59
You know, give us a brief background about it.
4:02
Yeah.
4:02
So, you know, my lab, we've been mostly interested in, um, molecular mechanisms of memory storage and how memories are encoded in the brain.
4:13
Um, and we know that when you learn something, a whole new gene program gets turned on in neurons, and most of those genes are master transcription factors that induce a wave of expression to modify the state of the cell so that it, it can encode information.
4:32
Um, but a couple of these so-called immediate early genes, um, encode proteins that are not transcription factors, and Arc is one of them.
4:41
So it's highly dynamic.
4:43
It's induced by learning.

27 MINS LATER

31:47
Hmm.

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