From a broad level, first of all, what is this potential connection? Where did that emerge from that we started to see a potential interaction between gut bacteria and medications? Yes.

As you know, there is a huge variability in the effect of the drugs we take in terms of efficacy and in terms of toxicity.

Some patients will, I mean, respond perfectly to a drug and not experience any side effects.

And another one with the same drug, same disease, will not see any efficacy and experience side effects.

With all the progresses in human genetics, we thought that this will solve this question and we'll understand from the host genetics this variability.

But the truth is it didn't work.

There are a few examples where it worked, but this is really a very tiny minority.

Can you maybe talk through that work that led to that, some of the background context for it and what you're specifically working on just to make people aware of? Sure.