W- what do we know about what's driving that acceleration?

Yeah, so I think it's a complicated number of factors that causes it.

So y- as you said, in that 10 years, um, from the onset of menopause, the risk of stroke in, in women doubles.

You know, and that's been known for a while, that after menopause, the risk of stroke in women starts to go up, and it was thought to and seen to correlate with estrogen levels, um, going down.

Uh, so in the 1990s, there was this idea that perhaps giving estrogen, estrogen supplementation, um, would help, um, with preventing strokes, which was certainly, like, a reasonable, um, idea and proposition.

But actually, over a series of several trials, um, what they saw is that estrogen or hormonal therapy in the studies that they looked at led to an increased risk of stroke, so that we know that, um, estrogen, that hormone therapy can, um, increase risk of clotting, but with the important caveat that that's most increased, um, in a certain specific populations, and there's a lot of things that sort of modulate that risk.

Um-

Mm-hmm