Following up on that, if I could ask, what do we currently know about changes in the skin environment which might drive neuroinflammation during neurotoxic chemotherapy treatment?

Yeah, this is still an emerging and relatively underdeveloped area in CIPN.

But this is actually one of the areas I find most exciting.

Historically, skin has often been treated mainly as the place where we measure intraepidermal nerve fiber loss, which is the loss of sensory nerve endings embedded in the epidermis.

But as you can imagine, skin is not a passive organ.

Sensory nerve endings sit in close contact with keratinocytes, fibroblasts, vascular cells, and immune cells.

So together, these cells form an active neurocutaneous environment.

What experimental models do you think are critical for further understanding in this research area? And I suppose linking between this preclinical and clinical work, as you've mentioned.

Following up on that, if I could ask, what do we currently know about changes in the skin environment which might drive neuroinflammation during neurotoxic chemotherapy treatment?

Yeah, this is still an emerging and relatively underdeveloped area in CIPN.

But this is actually one of the areas I find most exciting.

Historically, skin has often been treated mainly as the place where we measure intraepidermal nerve fiber loss, which is the loss of sensory nerve endings embedded in the epidermis.

But as you can imagine, skin is not a passive organ.

Sensory nerve endings sit in close contact with keratinocytes, fibroblasts, vascular cells, and immune cells.

So together, these cells form an active neurocutaneous environment.

What experimental models do you think are critical for further understanding in this research area? And I suppose linking between this preclinical and clinical work, as you've mentioned.

Describe it in your words.

Okay, well, to be honest, I watched the match at home because early morning and I had my FaceTime on to connect with my family back at home.

We were watching it together virtually, but I was literally at the edge of my seat.

My palms were sweaty because South Korea never won an opening match at the World Cup since 2010, I believe.

And a lot of the casters that I searched up on YouTube before watching today's match were saying that it's really important to start the World Cup strong, but that's never been history for Team Seoul.

So we wanted to see whether they could actually make it, especially since the list of this year's players are considered the gujjo in Korean, which is like the honey group or like the best of the best.

So I really had my hopes up high.

This is the point.